Clearstem contains ingredients like vitamins, DIM (diindolylmethane), and 5-HTP. We aren’t sure of the effects of 5-HTP on acne as it is usually sold as a calming supplement. This is why people may feel tired when they take it and it is probably best to take it in the evening.
Other adverse reactions like skin becoming worse and headaches have been reported as DIM can have this effect.
Take caution with DIM as if your estrogen levels are already low you can experience more side effects.
If you’re looking for a Clearstem alternative, check out Acnetame. Search Acnetame acne pills on Amazon and look for the red bottle.