How does CaMKII sense specific calcium waves?

John Kuriyan and his team reveal a flower-like unfurling mechanism that allows different isoforms of CaMKII to sense particular frequencies of calcium spikes. Check out the paper at: (11)00876-2 Chao, L.H., Stratton, M.M., Lee, I.H., Rosenberg, O.S., Levitz, J. , Mandell, D.J., Kortemme, T., Groves, J.T., Schulman, H., and Kuriyan, J. (2011). A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2 /Calmodulin- Dependent Kinase II Holoenzyme. Cell